Butabarbital will decrease the extent or result of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Impact of coadministering a powerful CYP3A4 inducer with fedratinib has not been researched. butabarbital will lower the level or influence of carvedilol by impacting hepatic enzyme CYP2C9/10 metabolism. https://smedleya416idz8.wikigdia.com/user