There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent discomfort transmission and deliver analgesia. As a result, medications like clonidine that concentrate on alpha-2 receptors can affect the transmission of ache. One of several theories https://www.proleviate.com/post/the-new-pain-killer-conolidine