Contraindicated (1)pentobarbital will reduce the extent or influence of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's Energetic metabolites. pentobarbital will lower the level or result of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significan... https://hught716yjq0.wikififfi.com/user