Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions... https://harlant887xjs5.blogdal.com/profile